蛋白质测序，DAPP1 的 SH2 和 PH 结构域与其他具有这些结构域的蛋白质的比对

DAPP1（a dual adaptor for phosphotyrosine and 3-phosphoinositides）即磷酸酪氨酸和 3-磷酸肌醇的双接头蛋白，含有SH2和PH两个结构域，又名Bam32（for B cell adaptor molecule of 32kD）。Bam32 在 B 细胞上被酪氨酸磷酸化抗原受体 (BCR) 连接或过钒酸盐刺激并与磷脂酶结合。BCR 连接后，Bam32 通过其 PH 结构域被募集到质膜。膜募集需要磷脂酰肌醇 3-激酶 (PI3K) 活性和完整的PI(3,4,5)P3 结合基序，表明膜募集是通过与3-磷酸肌醇结合。Bam32 在B细胞中的表达导致剂量依赖性抑制BCR 诱导活化T细胞核因子 (NF-AT) 的活化，其被阻断PH 结构域的缺失或 PI(3,4,5)P3 结合基序的突变。因此，Bam32代表了一种新型B细胞相关接头，可调节PI3K下游的BCR信号传导。

参考文献:

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Hao Li., Marshall Aaron J., Liu Lixin.(2021). Suppressive Role of Bam32/DAPP1 in Chemokine-Induced Neutrophil Recruitment. Int J Mol Sci, 22(4), undefined. doi:10.3390/ijms22041825

参考网站：

泛癌分析：http://gepia.cancer-pku.cn/detail.php?gene=DAPP1

作为药物靶点的信息：https://go.drugbank.com/polypeptides/Q9UN19